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Table 9.6d

Immunosuppression Use for Maintenance by Regimen

Prior to Discharge, 1999 to 2008

Recipients with Liver Transplants

  Transplant Year
1999 2000 2001 2002 2003 2004 2005 2006 2007 2008
Functioning Graft at Discharge 4,093 4,321 4,573 4,778 5,122 5,622 5,864 6,127 5,999 5,884
With Immunosuppression Info 3,944 4,303 4,566 4,774 5,116 5,595 5,793 6,061 5,964 5,826
CyA 1.2% 0.2% 0.7% 0.2% 0.4% 0.2% 0.2% 0.1% 0.1% 0.2%
Tac 2.3% 1.4% 3.4% 4.8% 7.6% 9.8% 10.0% 5.5% 4.6% 3.7%
--- + MMF/MPA 0.1% 0.0% 0.1% 0.1% 0.3% 0.3% 0.2% 0.4% 0.3% 0.2%
CyA + MMF/MPA 0.3% 0.3% 0.2% 0.2% 0.4% 0.8% 0.6% 0.9% 1.2% 0.9%
Tac + MMF/MPA 1.6% 2.5% 2.6% 2.8% 6.5% 6.3% 8.4% 12.8% 15.6% 13.8%
--- + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.0% 0.0% 0.0% 0.0%
CyA + OtherAntimet 0.3% 0.0% 0.0% 0.1% 0.5% 0.5% 0.0% 0.0% 0.0% 0.0%
Tac + OtherAntimet 0.2% 0.1% 0.1% 0.0% 0.3% 0.3% 0.3% 0.1% 0.2% 0.0%
CyA + MMF/MPA + OtherAntimet 0.2% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
Tac + MMF/MPA + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
--- + Siro/Evero 0.0% 0.0% 0.0% 0.1% 0.1% 0.1% 0.2% 0.1% 0.1% 0.0%
CyA + Siro/Evero 0.0% 0.7% 0.4% 0.0% 0.0% 0.0% 0.3% 0.6% 0.5% 0.3%
Tac + Siro/Evero 0.0% 1.0% 1.1% 0.4% 0.2% 0.4% 0.1% 0.2% 0.1% 0.1%
--- + MMF/MPA + Siro/Evero 0.0% 0.0% 0.0% 0.1% 0.2% 0.1% 0.1% 0.2% 0.2% 0.3%
CyA + MMF/MPA + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.0% 0.0% 0.1% 0.0%
Tac + MMF/MPA + Siro/Evero 0.0% 0.0% 0.2% 0.1% 0.2% 0.1% 0.1% 0.1% 0.1% 0.0%
--- + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
CyA + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
Tac + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%
--- + Steroids 1.7% 2.8% 2.2% 0.8% 0.8% 1.4% 0.8% 0.7% 0.8% 1.4%
CyA + Steroids 9.7% 6.1% 2.6% 2.1% 1.4% 1.0% 1.1% 0.5% 0.7% 0.5%
Tac + Steroids 38.8% 32.1% 32.3% 35.4% 29.4% 26.2% 24.0% 21.5% 19.2% 16.0%
--- + MMF/MPA + Steroids 1.1% 0.6% 0.9% 0.9% 0.9% 1.2% 0.9% 1.0% 1.1% 1.4%
CyA + MMF/MPA + Steroids 8.5% 6.6% 5.5% 4.6% 3.8% 3.3% 3.1% 3.0% 3.0% 3.5%
Tac + MMF/MPA + Steroids 24.1% 30.5% 35.1% 36.6% 39.5% 41.4% 44.8% 48.1% 48.9% 54.7%
--- + OtherAntimet + Steroids 0.3% 0.0% 0.0% 0.0% 0.3% 0.0% 0.0% 0.0% 0.0% 0.0%
CyA + OtherAntimet + Steroids 3.7% 2.6% 1.2% 1.2% 0.1% 0.5% 0.2% 0.1% 0.1% 0.1%
Tac + OtherAntimet + Steroids 2.7% 1.9% 1.4% 2.0% 1.8% 0.6% 0.1% 0.1% 0.2% 0.2%
--- + Siro/Evero + Steroids 0.0% 0.4% 0.4% 0.4% 0.2% 0.3% 0.2% 0.2% 0.2% 0.1%
CyA + Siro/Evero + Steroids 0.3% 0.4% 0.3% 0.6% 0.5% 0.4% 0.3% 0.1% 0.1% 0.2%
Tac + Siro/Evero + Steroids 0.1% 4.6% 4.6% 2.6% 1.0% 1.4% 0.9% 1.0% 0.4% 0.3%
Other Regimen 3.0% 5.0% 4.7% 3.9% 3.4% 3.1% 2.8% 2.4% 2.4% 2.2%


Source: OPTN/SRTR Data as of May 4, 2009.

Percentages in each column sum to 100 percent.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.



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