Table 7.6f

Immunosuppression Use for Maintenance by Regimen

One Year Following Transplantation, 1998 to 2007

Recipients with Pancreas After Kidney (PAK) Transplants

	Transplant Year
	1998	1999	2000	2001	2002	2003	2004	2005	2006	2007
Transplants	156	220	305	305	375	344	420	343	293	261
Functioning Graft at 1 Year PostTx	110	167	220	245	272	259	321	255	223	209
With Maintenance Use Recorded at 1 Year PostTx	70	163	212	242	267	251	319	254	220	206
Tac	0.0%	0.0%	0.9%	0.0%	0.7%	1.6%	5.3%	2.8%	1.8%	1.5%
--- + MMF/MPA	0.0%	0.0%	0.0%	0.0%	0.4%	1.6%	3.1%	0.0%	0.0%	0.5%
CyA + MMF/MPA	0.0%	0.0%	0.0%	0.4%	0.7%	0.8%	0.9%	1.2%	1.4%	1.9%
Tac + MMF/MPA	0.0%	1.2%	2.8%	4.1%	3.4%	7.6%	8.5%	18.5%	19.5%	24.3%
Tac + OtherAntimet	1.4%	0.0%	0.9%	0.0%	0.0%	0.8%	0.0%	0.4%	0.0%	1.0%
--- + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.3%	0.0%	0.0%	0.0%
CyA + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.6%	0.4%	2.3%	0.5%
Tac + Siro/Evero	0.0%	0.0%	0.9%	4.1%	7.5%	4.4%	7.2%	4.7%	4.5%	5.3%
--- + MMF/MPA + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.0%	0.8%	0.3%	1.6%	1.4%	1.5%
Tac + MMF/MPA + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.4%	1.2%	1.3%	2.4%	1.8%	7.8%
CyA + OtherAntimet + Siro/Evero	0.0%	0.0%	0.0%	0.4%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
--- + Steroids	0.0%	0.0%	0.5%	0.0%	0.0%	0.4%	0.0%	0.0%	0.0%	0.0%
CyA + Steroids	1.4%	0.0%	0.9%	0.4%	0.4%	1.2%	0.0%	0.4%	0.0%	0.0%
Tac + Steroids	1.4%	3.7%	4.7%	4.1%	4.1%	3.2%	2.2%	0.8%	3.6%	2.9%
--- + MMF/MPA + Steroids	0.0%	0.6%	0.5%	0.4%	0.4%	0.0%	0.3%	0.4%	1.8%	0.5%
CyA + MMF/MPA + Steroids	22.9%	9.2%	8.0%	8.3%	9.7%	5.2%	4.1%	2.0%	2.7%	1.9%
Tac + MMF/MPA + Steroids	62.9%	73.0%	54.2%	55.4%	53.2%	45.8%	50.8%	54.7%	50.9%	45.6%
--- + OtherAntimet + Steroids	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.5%	0.0%
CyA + OtherAntimet + Steroids	1.4%	0.6%	0.5%	0.0%	0.4%	0.0%	0.0%	0.4%	0.0%	0.0%
Tac + OtherAntimet + Steroids	4.3%	4.3%	2.4%	0.8%	0.4%	1.6%	0.9%	0.8%	1.8%	0.5%
--- + Siro/Evero + Steroids	0.0%	0.6%	0.5%	0.8%	0.4%	0.4%	0.0%	0.0%	0.5%	0.5%
CyA + Siro/Evero + Steroids	1.4%	1.8%	2.8%	1.2%	1.9%	0.8%	0.6%	0.8%	0.5%	0.0%
Tac + Siro/Evero + Steroids	0.0%	3.7%	14.6%	15.3%	10.9%	10.0%	7.2%	4.3%	3.6%	1.0%
Other Regimen	2.9%	1.2%	4.7%	4.1%	5.2%	12.7%	6.3%	3.5%	1.4%	2.9%

Source: OPTN/SRTR Data as of May 4, 2009.

Percentages are calculated based on the total number of patients with maintenance use at one year following transplantation. They sum to 100 percent for each column.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.