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Table 15.12

Immunosuppression Use for Maintenance by Regimen

Two Years Following Transplantation, 1998 to 2006

Recipients with Intestine Transplants

  Transplant Year
1998 1999 2000 2001 2002 2003 2004 2005 2006
Transplants 70 73 82 113 107 116 152 178 175
Functioning Graft at 2 Years PostTx 29 30 47 59 64 76 105 112 108
With Maintenance Use Recorded at 2 Years PostTx 29 30 47 59 64 76 104 102 91
CyA 0.0% 0.0% 0.0% 0.0% 0.0% 1.3% 0.0% 0.0% 0.0%
Tac 6.9% 3.3% 6.4% 28.8% 20.3% 42.1% 35.6% 41.2% 38.5%
Tac + MMF/MPA 0.0% 3.3% 0.0% 0.0% 1.6% 1.3% 1.0% 0.0% 2.2%
Tac + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 1.3% 1.0% 2.0% 1.1%
--- + Siro/Evero 0.0% 0.0% 0.0% 0.0% 1.6% 0.0% 1.0% 2.0% 0.0%
CyA + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 1.0% 0.0%
Tac + Siro/Evero 0.0% 6.7% 4.3% 3.4% 3.1% 2.6% 5.8% 2.0% 4.4%
--- + Steroids 0.0% 0.0% 4.3% 0.0% 3.1% 1.3% 1.0% 0.0% 0.0%
CyA + Steroids 0.0% 0.0% 0.0% 0.0% 0.0% 1.3% 0.0% 1.0% 1.1%
Tac + Steroids 79.3% 63.3% 53.2% 57.6% 50.0% 34.2% 36.5% 31.4% 40.7%
Tac + MMF/MPA + Steroids 6.9% 0.0% 2.1% 0.0% 7.8% 5.3% 5.8% 2.9% 7.7%
Tac + OtherAntimet + Steroids 3.4% 3.3% 0.0% 1.7% 0.0% 1.3% 1.9% 1.0% 0.0%
--- + Siro/Evero + Steroids 0.0% 0.0% 0.0% 0.0% 1.6% 0.0% 2.9% 2.0% 0.0%
Tac + Siro/Evero + Steroids 3.4% 16.7% 29.8% 8.5% 10.9% 7.9% 7.7% 13.7% 4.4%
Other Regimen 0.0% 3.3% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%


Source: OPTN/SRTR Data as of May 4, 2009.

Percentages are calculated based on the total number of patients with maintenance use at two years following transplantation. They sum to 100 percent for each column.

Transplants prior to year 1998 are not reported due to insufficient reporting of immunosuppressive drug use.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.



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