Table 15.10

Immunosuppression Use for Maintenance by Regimen

Two Years Following Transplantation, 1998 to 2006

Recipients with Kidney-Pancreas Transplants

	Transplant Year
	1998	1999	2000	2001	2002	2003	2004	2005	2006
Transplants	972	941	915	891	905	871	881	903	924
Functioning Graft at 2 Years PostTx	831	815	797	749	778	746	754	785	777
With Maintenance Use Recorded at 2 Years PostTx	799	784	781	722	767	736	744	654	560
CyA	0.1%	0.0%	0.0%	0.1%	0.4%	0.0%	0.0%	0.2%	0.2%
Tac	0.6%	0.1%	0.3%	1.8%	2.5%	1.4%	1.5%	2.3%	3.0%
--- + MMF/MPA	0.0%	0.0%	0.0%	0.1%	0.0%	0.3%	0.4%	0.2%	0.4%
CyA + MMF/MPA	0.0%	0.0%	0.0%	0.3%	0.3%	0.4%	0.4%	0.8%	0.9%
Tac + MMF/MPA	1.4%	2.4%	3.7%	5.3%	6.0%	7.3%	13.7%	15.4%	17.3%
CyA + OtherAntimet	0.0%	0.0%	0.1%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
Tac + OtherAntimet	0.3%	0.5%	0.1%	0.0%	0.3%	0.1%	0.4%	0.2%	0.0%
Tac + MMF/MPA + OtherAntimet	0.0%	0.0%	0.1%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
--- + Siro/Evero	0.0%	0.0%	0.0%	0.1%	0.4%	0.1%	0.1%	0.2%	0.4%
CyA + Siro/Evero	0.0%	0.1%	0.1%	0.3%	0.3%	1.2%	1.9%	2.3%	2.9%
Tac + Siro/Evero	0.0%	0.4%	3.3%	7.6%	8.2%	9.4%	5.9%	7.0%	2.9%
--- + MMF/MPA + Siro/Evero	0.0%	0.0%	0.0%	0.4%	0.3%	1.8%	4.6%	1.7%	1.3%
CyA + MMF/MPA + Siro/Evero	0.0%	0.1%	0.3%	0.0%	0.0%	0.0%	0.1%	0.2%	0.0%
Tac + MMF/MPA + Siro/Evero	0.0%	0.0%	0.3%	1.0%	0.4%	1.1%	0.9%	0.9%	3.4%
--- + Steroids	0.4%	0.3%	0.0%	0.8%	0.8%	0.5%	0.1%	0.2%	0.5%
CyA + Steroids	1.3%	1.0%	1.3%	1.0%	0.1%	0.4%	0.4%	0.2%	0.7%
Tac + Steroids	7.4%	7.5%	6.0%	5.3%	5.0%	4.8%	2.7%	4.1%	6.3%
--- + MMF/MPA + Steroids	0.4%	0.5%	0.3%	0.8%	0.9%	0.0%	1.1%	0.2%	0.0%
CyA + MMF/MPA + Steroids	23.5%	19.4%	11.0%	9.3%	8.3%	7.3%	3.4%	3.2%	1.6%
Tac + MMF/MPA + Steroids	53.1%	55.9%	53.1%	46.8%	49.2%	51.2%	52.0%	52.3%	49.5%
--- + OtherAntimet + Steroids	0.1%	0.0%	0.0%	0.0%	0.0%	0.0%	0.1%	0.0%	0.0%
CyA + OtherAntimet + Steroids	1.5%	0.1%	0.1%	0.1%	0.4%	0.0%	0.3%	0.0%	0.0%
Tac + OtherAntimet + Steroids	4.0%	3.3%	2.8%	0.8%	2.5%	1.9%	1.5%	1.5%	1.4%
--- + Siro/Evero + Steroids	0.0%	0.6%	0.5%	0.3%	0.4%	0.7%	0.1%	0.6%	0.0%
CyA + Siro/Evero + Steroids	0.4%	0.9%	2.6%	2.6%	0.9%	1.5%	0.3%	0.3%	0.4%
Tac + Siro/Evero + Steroids	1.4%	2.0%	6.4%	11.2%	8.6%	5.0%	5.4%	3.8%	3.8%
Other Regimen	4.3%	4.7%	7.6%	3.9%	4.0%	3.5%	2.7%	2.4%	3.4%

Source: OPTN/SRTR Data as of May 4, 2009.

Percentages are calculated based on the total number of patients with maintenance use at two years following transplantation. They sum to 100 percent for each column.

Transplants prior to year 1998 are not reported due to insufficient reporting of immunosuppressive drug use.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.