Table 15.7

Immunosuppression Use for Maintenance by Regimen

Two Years Following Transplantation, 1998 to 2005

Recipients with Kidney Transplants

	Transplant Year
	1998	1999	2000	2001	2002	2003	2004	2005
Transplants	12,452	12,760	13,613	14,266	14,779	15,137	16,004	16,482
Functioning Graft at 2 Years PostTx	9,961	10,203	11,062	11,833	12,312	12,635	13,382	13,717
With Maintenance Use Recorded at 2 Years PostTx	9,407	9,686	10,831	11,528	11,994	12,347	13,038	11,034
CyA	0.3%	0.7%	0.2%	0.2%	0.1%	0.1%	0.1%	0.1%
Tac	0.8%	0.8%	0.8%	1.5%	1.8%	1.9%	2.3%	3.1%
--- + MMF/MPA	0.1%	0.1%	0.1%	0.1%	0.1%	0.3%	0.3%	0.3%
CyA + MMF/MPA	1.3%	1.1%	1.4%	1.5%	1.7%	2.3%	2.3%	2.1%
Tac + MMF/MPA	1.8%	2.2%	2.9%	4.4%	6.5%	9.9%	15.5%	22.1%
--- + OtherAntimet	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
CyA + OtherAntimet	0.4%	0.2%	0.1%	0.1%	0.1%	0.0%	0.1%	0.1%
Tac + OtherAntimet	0.3%	0.2%	0.2%	0.2%	0.3%	0.2%	0.3%	0.4%
--- + MMF/MPA + OtherAntimet	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
CyA + MMF/MPA + OtherAntimet	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
Tac + MMF/MPA + OtherAntimet	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
--- + Siro/Evero	0.0%	0.0%	0.2%	0.3%	0.2%	0.2%	0.2%	0.2%
CyA + Siro/Evero	0.6%	0.2%	0.3%	0.4%	0.8%	0.8%	0.8%	1.0%
Tac + Siro/Evero	0.0%	0.1%	0.9%	2.1%	2.4%	2.7%	2.1%	1.6%
--- + MMF/MPA + Siro/Evero	0.0%	0.0%	0.2%	0.5%	0.7%	1.4%	1.9%	2.4%
CyA + MMF/MPA + Siro/Evero	0.0%	0.0%	0.1%	0.1%	0.0%	0.1%	0.0%	0.0%
Tac + MMF/MPA + Siro/Evero	0.0%	0.1%	0.2%	0.3%	0.5%	0.8%	0.7%	0.8%
--- + OtherAntimet + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
CyA + OtherAntimet + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
Tac + OtherAntimet + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
--- + Steroids	0.6%	0.7%	0.3%	0.5%	0.4%	0.5%	0.3%	0.2%
CyA + Steroids	8.0%	6.9%	4.1%	2.4%	1.5%	1.4%	0.9%	0.7%
Tac + Steroids	6.5%	7.2%	7.4%	6.5%	6.1%	5.1%	4.5%	4.4%
--- + MMF/MPA + Steroids	1.6%	1.9%	1.4%	1.3%	1.3%	1.1%	1.2%	1.1%
CyA + MMF/MPA + Steroids	39.7%	36.2%	31.0%	22.8%	18.5%	14.0%	12.1%	7.4%
Tac + MMF/MPA + Steroids	23.2%	27.4%	29.7%	35.0%	38.6%	41.3%	40.0%	40.4%
--- + OtherAntimet + Steroids	0.2%	0.1%	0.1%	0.1%	0.1%	0.1%	0.1%	0.1%
CyA + OtherAntimet + Steroids	6.6%	4.6%	2.9%	1.5%	0.7%	0.5%	0.3%	0.2%
Tac + OtherAntimet + Steroids	2.6%	2.1%	2.0%	2.0%	1.6%	1.4%	1.3%	1.3%
--- + Siro/Evero + Steroids	0.2%	0.5%	0.7%	1.0%	0.7%	0.9%	0.9%	0.9%
CyA + Siro/Evero + Steroids	2.3%	2.3%	3.7%	2.9%	2.5%	1.9%	1.3%	1.1%
Tac + Siro/Evero + Steroids	0.5%	1.4%	4.8%	6.5%	5.6%	4.4%	3.2%	2.2%
Other Regimen	2.3%	3.0%	4.2%	5.8%	6.9%	6.7%	7.1%	5.7%

Source: OPTN/SRTR Data as of May 1, 2008.

Percentages are calculated based on the total number of patients with maintenance use at two years following transplantation. They sum to 100 percent for each column.

Transplants prior to year 1998 are not reported due to insufficient reporting of immunosuppressive drug use.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.