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Table 15.6

Steroid Withdrawal Rate at One Year Following Transplantation, 1999 to 2007

Recipients of Heart Transplants

Discharge Regimen Year of Transplant
1999 2000 2001 2002 2003 2004 2005 2006 2007
Total Patients 1,591 1,596 1,691 1,679 1,518 1,538 1,587 1,623 1,605
Steroids Withdrawn 303 279 359 391 390 359 441 445 467
Rate 19.0% 17.5% 21.2% 23.3% 25.7% 23.3% 27.8% 27.4% 29.1%
CyA Patients 191 67 27 43 25 11 10 23 18
Steroids Withdrawn 29 7 5 13 4 3 3 2 3
Rate 15.2% 10.4% 18.5% 30.2% 16.0% 27.3% 30.0% 8.7% 16.7%
Tac Patients 37 34 59 64 42 32 34 27 39
Steroids Withdrawn 19 12 14 20 11 10 16 14 9
Rate 51.4% 35.3% 23.7% 31.3% 26.2% 31.3% 47.1% 51.9% 23.1%
CyA+MMF Patients 670 936 926 743 701 667 550 522 442
Steroids Withdrawn 136 161 177 161 159 158 133 136 113
Rate 20.3% 17.2% 19.1% 21.7% 22.7% 23.7% 24.2% 26.1% 25.6%
Tac+MMF Patients 119 134 320 393 444 597 770 852 950
Steroids Withdrawn 19 25 80 75 121 143 243 242 311
Rate 16.0% 18.7% 25.0% 19.1% 27.3% 24.0% 31.6% 28.4% 32.7%
CyA+Aza Patients 415 246 171 115 76 65 38 36 25
Steroids Withdrawn 75 40 40 30 22 12 5 11 3
Rate 18.1% 16.3% 23.4% 26.1% 28.9% 18.5% 13.2% 30.6% 12.0%
Tac+Aza Patients 31 35 21 21 19 17 16 21 12
Steroids Withdrawn 3 7 2 4 6 2 7 7 5
Rate 9.7% 20.0% 9.5% 19.0% 31.6% 11.8% 43.8% 33.3% 41.7%
CyA+Siro Patients 11 10 3 17 34 2 1 2 -
Steroids Withdrawn 1 2 1 11 17 0 0 0 -
Rate 9.1% 20.0% 33.3% 64.7% 50.0% 0.0% 0.0% 0.0% -
Tac+Siro Patients 1 2 36 101 30 12 14 11 0
Steroids Withdrawn 0 0 2 23 11 3 5 8 -
Rate 0.0% 0.0% 5.6% 22.8% 36.7% 25.0% 35.7% 72.7% -
Siro+MMF Patients - - 3 5 16 14 14 18 3
Steroids Withdrawn - - 1 0 3 1 1 3 0
Rate - - 33.3% 0.0% 18.8% 7.1% 7.1% 16.7% 0.0%
Other Regimen Patients 116 132 125 177 131 121 140 111 116
Steroids Withdrawn 21 25 37 54 36 27 28 22 23
Rate 18.1% 18.9% 29.6% 30.5% 27.5% 22.3% 20.0% 19.8% 19.8%


Source: OPTN/SRTR Data as of May 4, 2009.

Includes patients receiving first transplants of any organ with steroid use at transplant discharge, and who have a functioning graft and maintenance drug use one year after transplantation.

Transplants prior to year 1999 are not reported due to insufficient reporting of immunosuppressive drug use.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.



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