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Table 15.5b

Steroid Withdrawal Rate at One Year Following Transplantation, 1999 to 2007

Recipients of Living Donor Livers

Discharge Regimen Year of Transplant
1999 2000 2001 2002 2003 2004 2005 2006 2007
Total Patients 149 263 368 252 195 202 200 170 151
Steroids Withdrawn 36 83 164 121 91 98 101 81 89
Rate 24.2% 31.6% 44.6% 48.0% 46.7% 48.5% 50.5% 47.6% 58.9%
CyA Patients 10 15 7 5 6 - 1 1 -
Steroids Withdrawn 1 3 4 3 2 - 1 1 -
Rate 10.0% 20.0% 57.1% 60.0% 33.3% - 100.0% 100.0% -
Tac Patients 75 101 131 93 68 65 60 66 56
Steroids Withdrawn 25 34 58 43 28 36 27 28 31
Rate 33.3% 33.7% 44.3% 46.2% 41.2% 55.4% 45.0% 42.4% 55.4%
CyA+MMF Patients 10 17 22 16 13 11 7 2 4
Steroids Withdrawn 2 4 11 10 11 7 5 2 2
Rate 20.0% 23.5% 50.0% 62.5% 84.6% 63.6% 71.4% 100.0% 50.0%
Tac+MMF Patients 37 94 152 105 98 108 118 96 77
Steroids Withdrawn 6 25 65 55 48 49 61 50 51
Rate 16.2% 26.6% 42.8% 52.4% 49.0% 45.4% 51.7% 52.1% 66.2%
CyA+Aza Patients 3 3 1 4 2 2 2 - 3
Steroids Withdrawn 0 1 0 0 1 0 1 - 0
Rate 0.0% 33.3% 0.0% 0.0% 50.0% 0.0% 50.0% - 0.0%
Tac+Aza Patients 4 2 - 2 - - 0 - 1
Steroids Withdrawn 1 1 - 1 - - - - 0
Rate 25.0% 50.0% - 50.0% - - - - 0.0%
CyA+Siro Patients - 3 3 2 - 1 - - -
Steroids Withdrawn - 3 2 1 - 1 - - -
Rate - 100.0% 66.7% 50.0% - 100.0% - - -
Tac+Siro Patients - 12 23 9 1 2 1 1 3
Steroids Withdrawn - 5 10 4 0 2 1 0 1
Rate - 41.7% 43.5% 44.4% 0.0% 100.0% 100.0% 0.0% 33.3%
Siro+MMF Patients - 1 4 2 1 1 1 - 2
Steroids Withdrawn - 0 2 2 0 1 1 - 2
Rate - 0.0% 50.0% 100.0% 0.0% 100.0% 100.0% - 100.0%
Other Regimen Patients 10 15 25 14 6 12 10 4 5
Steroids Withdrawn 1 7 12 2 1 2 4 0 2
Rate 10.0% 46.7% 48.0% 14.3% 16.7% 16.7% 40.0% 0.0% 40.0%


Source: OPTN/SRTR Data as of May 4, 2009.

Includes patients receiving first transplants of any organ with steroid use at transplant discharge, and who have a functioning graft and maintenance drug use one year after transplantation.

Transplants prior to year 1999 are not reported due to insufficient reporting of immunosuppressive drug use.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.



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