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Table 15.5a

Steroid Withdrawal Rate at One Year Following Transplantation, 1999 to 2006

Recipients of Deceased Donor Livers

Discharge Regimen Year of Transplant
1999 2000 2001 2002 2003 2004 2005 2006
Total Patients 2,684 2,894 2,995 3,235 3,201 3,439 3,378 3,556
Steroids Withdrawn 859 1,146 1,371 1,667 1,631 1,752 1,841 1,928
Rate 32.0% 39.6% 45.8% 51.5% 51.0% 50.9% 54.5% 54.2%
CyA Patients 287 193 92 75 51 42 41 25
Steroids Withdrawn 69 45 41 41 17 19 22 17
Rate 24.0% 23.3% 44.6% 54.7% 33.3% 45.2% 53.7% 68.0%
Tac Patients 1,075 995 1,073 1,269 1,139 1,159 1,042 956
Steroids Withdrawn 427 467 523 702 596 577 555 503
Rate 39.7% 46.9% 48.7% 55.3% 52.3% 49.8% 53.3% 52.6%
CyA+MMF Patients 272 224 188 150 139 139 143 141
Steroids Withdrawn 59 52 60 63 57 68 81 77
Rate 21.7% 23.2% 31.9% 42.0% 41.0% 48.9% 56.6% 54.6%
Tac+MMF Patients 703 956 1,172 1,331 1,545 1,763 1,913 2,216
Steroids Withdrawn 239 391 545 683 824 931 1,065 1,207
Rate 34.0% 40.9% 46.5% 51.3% 53.3% 52.8% 55.7% 54.5%
CyA+Aza Patients 124 97 47 44 1 24 12 5
Steroids Withdrawn 3 15 4 12 0 7 4 1
Rate 2.4% 15.5% 8.5% 27.3% 0.0% 29.2% 33.3% 20.0%
Tac+Aza Patients 88 64 59 77 80 26 3 3
Steroids Withdrawn 11 11 15 17 15 14 0 2
Rate 12.5% 17.2% 25.4% 22.1% 18.8% 53.8% 0.0% 66.7%
CyA+Siro Patients 3 13 8 21 18 19 17 3
Steroids Withdrawn 1 7 3 14 9 14 13 2
Rate 33.3% 53.8% 37.5% 66.7% 50.0% 73.7% 76.5% 66.7%
Tac+Siro Patients 4 135 134 85 41 52 37 43
Steroids Withdrawn 2 63 67 57 23 23 19 29
Rate 50.0% 46.7% 50.0% 67.1% 56.1% 44.2% 51.4% 67.4%
Siro+MMF Patients 2 27 39 34 32 31 30 24
Steroids Withdrawn 0 11 16 20 16 14 17 14
Rate 0.0% 40.7% 41.0% 58.8% 50.0% 45.2% 56.7% 58.3%
Other Regimen Patients 126 190 183 149 155 184 140 140
Steroids Withdrawn 48 84 97 58 74 85 65 76
Rate 38.1% 44.2% 53.0% 38.9% 47.7% 46.2% 46.4% 54.3%


Source: OPTN/SRTR Data as of May 1, 2008.

Includes patients receiving first transplants of any organ with steroid use at transplant discharge, and who have a functioning graft and maintenance drug use one year after transplantation.

Transplants prior to year 1999 are not reported due to insufficient reporting of immunosuppressive drug use.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.



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