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Table 15.5a

Steroid Withdrawal Rate at One Year Following Transplantation, 1999 to 2007

Recipients of Deceased Donor Livers

Discharge Regimen Year of Transplant
1999 2000 2001 2002 2003 2004 2005 2006 2007
Total Patients 2,678 2,893 2,995 3,235 3,199 3,438 3,374 3,569 3,388
Steroids Withdrawn 853 1,146 1,372 1,669 1,630 1,751 1,840 1,932 1,992
Rate 31.9% 39.6% 45.8% 51.6% 51.0% 50.9% 54.5% 54.1% 58.8%
CyA Patients 286 193 92 75 50 42 42 25 27
Steroids Withdrawn 68 45 41 41 17 19 23 17 16
Rate 23.8% 23.3% 44.6% 54.7% 34.0% 45.2% 54.8% 68.0% 59.3%
Tac Patients 1,073 994 1,074 1,269 1,139 1,159 1,039 951 833
Steroids Withdrawn 425 467 523 704 596 577 554 502 483
Rate 39.6% 47.0% 48.7% 55.5% 52.3% 49.8% 53.3% 52.8% 58.0%
CyA+MMF Patients 271 224 188 150 139 139 142 142 139
Steroids Withdrawn 58 52 61 63 57 68 81 78 80
Rate 21.4% 23.2% 32.4% 42.0% 41.0% 48.9% 57.0% 54.9% 57.6%
Tac+MMF Patients 702 956 1,171 1,331 1,544 1,762 1,912 2,233 2,220
Steroids Withdrawn 238 391 545 683 823 930 1,064 1,211 1,329
Rate 33.9% 40.9% 46.5% 51.3% 53.3% 52.8% 55.6% 54.2% 59.9%
CyA+Aza Patients 124 97 47 44 1 24 12 5 3
Steroids Withdrawn 3 15 4 12 0 7 4 1 2
Rate 2.4% 15.5% 8.5% 27.3% 0.0% 29.2% 33.3% 20.0% 66.7%
Tac+Aza Patients 87 64 59 77 80 26 3 3 8
Steroids Withdrawn 10 11 15 17 15 14 0 2 2
Rate 11.5% 17.2% 25.4% 22.1% 18.8% 53.8% 0.0% 66.7% 25.0%
CyA+Siro Patients 3 13 8 21 18 19 17 3 3
Steroids Withdrawn 1 7 3 14 9 14 13 2 1
Rate 33.3% 53.8% 37.5% 66.7% 50.0% 73.7% 76.5% 66.7% 33.3%
Tac+Siro Patients 4 135 134 85 41 52 37 43 16
Steroids Withdrawn 2 63 67 57 23 23 19 29 11
Rate 50.0% 46.7% 50.0% 67.1% 56.1% 44.2% 51.4% 67.4% 68.8%
Siro+MMF Patients 2 27 39 34 32 31 30 24 13
Steroids Withdrawn 0 11 16 20 16 14 17 14 8
Rate 0.0% 40.7% 41.0% 58.8% 50.0% 45.2% 56.7% 58.3% 61.5%
Other Regimen Patients 126 190 183 149 155 184 140 140 126
Steroids Withdrawn 48 84 97 58 74 85 65 76 60
Rate 38.1% 44.2% 53.0% 38.9% 47.7% 46.2% 46.4% 54.3% 47.6%


Source: OPTN/SRTR Data as of May 4, 2009.

Includes patients receiving first transplants of any organ with steroid use at transplant discharge, and who have a functioning graft and maintenance drug use one year after transplantation.

Transplants prior to year 1999 are not reported due to insufficient reporting of immunosuppressive drug use.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.



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