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Table 15.4b

Steroid Withdrawal Rate at Two Years Following Transplantation, 1998 to 2005

Recipients of Living Donor Kidneys

Discharge Regimen Year of Transplant
1998 1999 2000 2001 2002 2003 2004 2005
Total Patients 2,995 3,259 3,859 4,090 4,105 3,894 3,551 2,607
Steroids Withdrawn 200 185 270 382 528 567 570 466
Rate 6.7% 5.7% 7.0% 9.3% 12.9% 14.6% 16.1% 17.9%
CyA Patients 190 197 141 93 63 75 77 12
Steroids Withdrawn 13 11 10 12 3 4 6 1
Rate 6.8% 5.6% 7.1% 12.9% 4.8% 5.3% 7.8% 8.3%
Tac Patients 74 92 143 150 124 116 116 57
Steroids Withdrawn 11 13 21 23 16 18 24 13
Rate 14.9% 14.1% 14.7% 15.3% 12.9% 15.5% 20.7% 22.8%
CyA+MMF Patients 1,540 1,664 1,638 1,356 1,080 823 713 356
Steroids Withdrawn 75 75 57 73 74 54 64 34
Rate 4.9% 4.5% 3.5% 5.4% 6.9% 6.6% 9.0% 9.6%
Tac+MMF Patients 558 793 1,125 1,613 2,045 2,125 2,053 1,777
Steroids Withdrawn 40 50 96 167 266 325 342 301
Rate 7.2% 6.3% 8.5% 10.4% 13.0% 15.3% 16.7% 16.9%
CyA+Aza Patients 319 219 163 126 44 19 10 4
Steroids Withdrawn 27 8 7 4 2 0 0 0
Rate 8.5% 3.7% 4.3% 3.2% 4.5% 0.0% 0.0% 0.0%
Tac+Aza Patients 54 51 51 65 72 62 34 5
Steroids Withdrawn 15 10 13 17 17 4 5 1
Rate 27.8% 19.6% 25.5% 26.2% 23.6% 6.5% 14.7% 20.0%
CyA+Siro Patients 71 47 227 149 101 99 40 38
Steroids Withdrawn 6 3 26 13 34 32 3 6
Rate 8.5% 6.4% 11.5% 8.7% 33.7% 32.3% 7.5% 15.8%
Tac+Siro Patients - 4 159 278 258 223 156 104
Steroids Withdrawn - 1 14 47 58 53 30 19
Rate - 25.0% 8.8% 16.9% 22.5% 23.8% 19.2% 18.3%
Siro+MMF Patients 2 1 29 89 115 105 72 80
Steroids Withdrawn 0 0 1 2 23 20 12 25
Rate 0.0% 0.0% 3.4% 2.2% 20.0% 19.0% 16.7% 31.3%
Other Regimen Patients 187 191 183 171 203 247 280 174
Steroids Withdrawn 13 14 25 24 35 57 84 66
Rate 7.0% 7.3% 13.7% 14.0% 17.2% 23.1% 30.0% 37.9%


Source: OPTN/SRTR Data as of May 1, 2008.

Includes patients receiving first transplants of any organ with steroid use at transplant discharge, and who have a functioning graft and maintenance drug use two years after transplantation.

Transplants prior to year 1998 are not reported due to insufficient reporting of immunosuppressive drug use.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.



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