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Table 14.8

De Novo Posttransplant Solid Malignancy, 1999 to 2008

Liver Recipients

Malignancies by Type Year of Transplant
1999 2000 2001 2002 2003 2004 2005 2006 2007 2008
Total # of Post-Tx Malignancies 380 331 323 359 305 323 318 226 123 38
Squamous/Basal Cell Carcinoma 150 152 134 133 111 115 118 68 34 10
Melanoma 15 5 7 14 10 6 13 7 8 -
Kaposi Sarcoma 5 2 1 3 - 1 - - 2 -
Central Nervous System 2 1 3 2 2 4 1 5 4 -
Genito-Urinary (1) 32 34 38 28 41 28 28 18 11 4
Gastro-Intestinal (2) 52 35 36 28 36 38 28 29 14 5
Primary Hepatic Tumor 14 16 8 21 16 18 29 11 8 6
Metastatic Hepatic Tumor 6 9 13 17 13 20 21 15 7 2
Larynx/Bronchi/Lung 54 39 44 58 33 54 41 41 16 5
Breast/Thyroid 19 10 15 15 13 9 11 10 2 -
Leukemia - 2 1 2 5 6 2 - 3 -
Sarcoma (3) 1 1 - 3 3 2 2 - 1 -
Other 22 21 16 31 18 19 23 18 12 6
Unknown 8 4 7 4 4 3 1 4 1 -
Squamous/Basal Cell Carcinoma 39.5% 45.9% 41.5% 37.0% 36.4% 35.6% 37.1% 30.1% 27.6% 26.3%
Melanoma 3.9% 1.5% 2.2% 3.9% 3.3% 1.9% 4.1% 3.1% 6.5% -
Kaposi Sarcoma 1.3% 0.6% 0.3% 0.8% - 0.3% - - 1.6% -
Central Nervous System 0.5% 0.3% 0.9% 0.6% 0.7% 1.2% 0.3% 2.2% 3.3% -
Genito-Urinary (1) 8.4% 10.3% 11.8% 7.8% 13.4% 8.7% 8.8% 8.0% 8.9% 10.5%
Gastro-Intestinal (2) 13.7% 10.6% 11.1% 7.8% 11.8% 11.8% 8.8% 12.8% 11.4% 13.2%
Primary Hepatic Tumor 3.7% 4.8% 2.5% 5.8% 5.2% 5.6% 9.1% 4.9% 6.5% 15.8%
Metastatic Hepatic Tumor 1.6% 2.7% 4.0% 4.7% 4.3% 6.2% 6.6% 6.6% 5.7% 5.3%
Larynx/Bronchi/Lung 14.2% 11.8% 13.6% 16.2% 10.8% 16.7% 12.9% 18.1% 13.0% 13.2%
Breast/Thyroid 5.0% 3.0% 4.6% 4.2% 4.3% 2.8% 3.5% 4.4% 1.6% -
Leukemia - 0.6% 0.3% 0.6% 1.6% 1.9% 0.6% - 2.4% -
Sarcoma (3) 0.3% 0.3% - 0.8% 1.0% 0.6% 0.6% - 0.8% -
Other 5.8% 6.3% 5.0% 8.6% 5.9% 5.9% 7.2% 8.0% 9.8% 15.8%
Unknown 2.1% 1.2% 2.2% 1.1% 1.3% 0.9% 0.3% 1.8% 0.8% -
Total # of Patients 271 254 241 270 228 247 235 173 99 33


Source: OPTN/SRTR Data as of May 4, 2009.

(-) = None in category.

(1) Genito-Urinary: kidney, bladder, uterine cervix, uterine body, ovarian, vulva, testicular, prostate.

(2) Gastro-Intestinal: tongue, throat, esophagus, stomach, small intestine, colo-rectal, liver and biliary tract, pancreas.

(3) Sarcoma: fibrosarcoma, osteosarcoma, etc.

Recipient malignancy statistics are based on voluntary reporting to the OPTN.



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