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Table 11.6h

Persistency of Discharge Regimen by Follow-up Period, 2003 to 2007

Recipients with Heart Transplants

  Year of Transplant
2003 2004 2005 2006 2007
Discharge Regimen (w/ or w/o Steroid Use) CyA+Aza At Discharge (N) 94 84 48 43 30
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 45.2% 63.1% 76.7% 74.4% 72.4%
2 Years PostTx (%) 34.6% 41.3% 41.7% 46.9% -
3 Years PostTx (%) 29.8% 30.0% 32.3% 46.9% -
CyA+MMF At Discharge (N) 828 752 637 612 547
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 67.4% 77.9% 81.9% 81.0% 79.6%
2 Years PostTx (%) 55.1% 61.3% 65.4% 66.1% 61.6%
3 Years PostTx (%) 47.4% 52.3% 56.4% 55.6% -
CyA+Siro At Discharge (N) 39 2 2 2 -
At Discharge (%) 100.0% 100.0% 100.0% 100.0% -
1 Year PostTx (%) 51.3% 50.0% 100.0% 50.0% -
2 Years PostTx (%) 38.5% 50.0% 0.0% 50.0% -
3 Years PostTx (%) 33.0% 50.0% 0.0% - -
Siro+MMF At Discharge (N) 19 24 17 25 7
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 63.2% 75.0% 64.7% 87.5% 57.1%
2 Years PostTx (%) 52.6% 58.3% 64.7% 76.6% 57.1%
3 Years PostTx (%) 47.4% 54.2% 47.1% - -
Tac+Aza At Discharge (N) 26 23 20 27 20
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 60.0% 78.3% 60.0% 77.8% 67.9%
2 Years PostTx (%) 38.8% 60.9% 45.0% 54.9% -
3 Years PostTx (%) 25.8% 47.8% 36.0% 54.9% -
Tac+MMF At Discharge (N) 572 723 941 1,060 1,237
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 77.2% 83.8% 86.1% 87.5% 86.5%
2 Years PostTx (%) 68.9% 73.4% 75.7% 77.1% 73.2%
3 Years PostTx (%) 62.0% 66.5% 70.1% 72.0% -
Tac+Siro At Discharge (N) 36 19 23 26 7
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
1 Year PostTx (%) 66.7% 55.7% 82.6% 69.2% 85.7%
2 Years PostTx (%) 60.6% 44.6% 69.6% 64.9% -
3 Years PostTx (%) 57.4% 33.4% 58.4% - -


Source: OPTN/SRTR Data as of May 4, 2009.

Regimen change is defined as being on different drug combination at follow-up comparing to discharge, or indication of conflicting regimen (CyA vs. Tac; MMF/MPA vs. Aza; Siro vs. Evero) during follow-up period, or graft failure/death. Addition or deletion of steroids is not considered a regimen change.Rates are calculated for the most common discharge regimens.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.

See Technical Notes for further details.



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