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Table 11.6f

Immunosuppression Use for Maintenance by Regimen

One Year Following Transplantation, 1998 to 2007

Recipients with Heart Transplants

  Transplant Year
1998 1999 2000 2001 2002 2003 2004 2005 2006 2007
Transplants 2,348 2,188 2,199 2,202 2,155 2,057 2,015 2,125 2,193 2,209
Functioning Graft at 1 Year PostTx 1,940 1,780 1,820 1,850 1,823 1,755 1,748 1,807 1,899 1,924
With Maintenance Use Recorded at 1 Year PostTx 1,084 1,724 1,755 1,829 1,787 1,718 1,739 1,795 1,880 1,896
CyA 1.0% 0.9% 1.3% 0.8% 0.8% 0.8% 0.3% 0.3% 0.3% 0.4%
Tac 1.2% 1.3% 1.1% 0.7% 1.6% 1.3% 1.2% 2.4% 2.8% 2.6%
--- + MMF/MPA 0.2% 0.1% 0.2% 0.1% 0.2% 0.4% 0.2% 0.1% 0.2% 0.2%
CyA + MMF/MPA 7.6% 8.5% 9.7% 9.0% 8.6% 8.5% 8.3% 7.6% 6.7% 5.3%
Tac + MMF/MPA 2.2% 2.8% 3.4% 6.9% 6.3% 10.4% 10.8% 15.4% 16.6% 20.0%
--- + OtherAntimet 0.2% 0.2% 0.2% 0.1% 0.0% 0.1% 0.0% 0.0% 0.0% 0.0%
CyA + OtherAntimet 3.7% 3.3% 2.3% 1.6% 2.4% 1.2% 1.4% 0.7% 1.1% 0.8%
Tac + OtherAntimet 0.5% 0.9% 0.9% 0.9% 1.1% 1.0% 1.3% 1.1% 1.2% 2.0%
--- + MMF/MPA + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.0% 0.1% 0.0%
CyA + MMF/MPA + OtherAntimet 0.0% 0.0% 0.0% 0.1% 0.1% 0.0% 0.1% 0.1% 0.0% 0.0%
Tac + MMF/MPA + OtherAntimet 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.2% 0.0% 0.0%
--- + Siro/Evero 0.0% 0.0% 0.0% 0.1% 0.0% 0.2% 0.0% 0.0% 0.0% 0.1%
CyA + Siro/Evero 0.0% 0.1% 0.1% 0.2% 0.8% 0.8% 0.5% 0.2% 0.4% 0.4%
Tac + Siro/Evero 0.0% 0.0% 0.2% 0.2% 1.3% 1.5% 0.9% 1.5% 1.2% 1.1%
--- + MMF/MPA + Siro/Evero 0.0% 0.0% 0.0% 0.1% 0.1% 0.2% 0.2% 0.7% 0.5% 0.4%
CyA + MMF/MPA + Siro/Evero 0.0% 0.1% 0.1% 0.1% 0.2% 0.5% 0.1% 0.2% 0.1% 0.2%
Tac + MMF/MPA + Siro/Evero 0.0% 0.1% 0.0% 0.1% 0.3% 0.2% 0.3% 0.3% 0.5% 0.5%
--- + OtherAntimet + Siro/Evero 0.0% 0.0% 0.0% 0.0% 0.0% 0.1% 0.1% 0.1% 0.0% 0.1%
CyA + OtherAntimet + Siro/Evero 0.0% 0.1% 0.0% 0.0% 0.1% 0.0% 0.1% 0.0% 0.1% 0.0%
Tac + OtherAntimet + Siro/Evero 0.0% 0.0% 0.1% 0.0% 0.1% 0.0% 0.1% 0.0% 0.1% 0.0%
--- + Steroids 5.4% 2.0% 2.2% 3.4% 0.4% 0.2% 0.4% 0.1% 0.2% 0.1%
CyA + Steroids 2.6% 4.9% 3.6% 1.9% 1.9% 1.9% 0.9% 1.4% 1.1% 1.0%
Tac + Steroids 2.4% 2.3% 2.3% 4.3% 3.5% 3.1% 2.6% 2.8% 2.7% 2.4%
--- + MMF/MPA + Steroids 0.6% 0.5% 0.8% 0.5% 0.6% 0.3% 0.6% 0.4% 0.3% 0.3%
CyA + MMF/MPA + Steroids 36.3% 35.1% 41.0% 33.5% 27.8% 24.9% 23.6% 20.7% 18.7% 16.1%
Tac + MMF/MPA + Steroids 13.8% 14.6% 16.9% 21.2% 24.9% 25.7% 32.1% 33.5% 35.4% 36.6%
--- + OtherAntimet + Steroids 0.1% 0.1% 0.1% 0.2% 0.1% 0.1% 0.0% 0.0% 0.0% 0.0%
CyA + OtherAntimet + Steroids 15.0% 11.3% 6.6% 4.6% 3.2% 2.0% 2.8% 0.9% 1.1% 0.6%
Tac + OtherAntimet + Steroids 4.2% 3.4% 1.9% 2.6% 1.9% 2.0% 1.6% 1.3% 1.5% 1.6%
--- + Siro/Evero + Steroids 0.0% 0.1% 0.2% 0.4% 0.3% 0.2% 0.1% 0.2% 0.2% 0.3%
CyA + Siro/Evero + Steroids 0.2% 1.2% 1.3% 0.8% 1.2% 2.5% 1.0% 0.6% 2.1% 2.4%
Tac + Siro/Evero + Steroids 0.3% 0.5% 1.0% 2.8% 4.5% 4.4% 2.2% 2.1% 1.5% 0.9%
Other Regimen 2.6% 5.9% 2.7% 3.1% 6.0% 5.5% 6.3% 5.1% 3.5% 3.8%


Source: OPTN/SRTR Data as of May 4, 2009.

Percentages are calculated based on the total number of patients with maintenance use at one year following transplantation. They sum to 100 percent for each column.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.



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