Table 6.6f

Immunosuppression Use for Maintenance by Regimen

One Year Following Transplantation, 1998 to 2007

Recipients with Pancreas Transplant Alone (PTA) Transplants

	Transplant Year
	1998	1999	2000	2001	2002	2003	2004	2005	2006	2007
Transplants	88	139	134	168	181	160	183	199	173	208
Functioning Graft at 1 Year PostTx	63	109	96	122	141	115	137	148	125	151
With Maintenance Use Recorded at 1 Year PostTx	51	108	93	120	140	115	137	148	125	150
CyA	0.0%	0.0%	1.1%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
Tac	0.0%	1.9%	2.2%	10.8%	5.7%	17.4%	14.6%	18.9%	16.8%	7.3%
--- + MMF/MPA	0.0%	0.0%	0.0%	0.0%	1.4%	9.6%	3.6%	1.4%	0.8%	0.0%
CyA + MMF/MPA	0.0%	0.0%	0.0%	0.8%	1.4%	0.9%	0.7%	0.0%	0.8%	0.7%
Tac + MMF/MPA	0.0%	3.7%	2.2%	2.5%	7.9%	7.0%	11.7%	18.2%	15.2%	18.0%
Tac + OtherAntimet	0.0%	0.0%	0.0%	0.0%	0.0%	0.9%	0.7%	1.4%	0.0%	1.3%
--- + Siro/Evero	0.0%	0.0%	0.0%	1.7%	0.7%	0.9%	2.2%	0.0%	0.0%	0.0%
CyA + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.7%	1.7%	0.0%	0.7%	0.8%	0.0%
Tac + Siro/Evero	0.0%	0.9%	2.2%	0.8%	9.3%	7.0%	8.0%	8.8%	6.4%	5.3%
--- + MMF/MPA + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.0%	0.9%	0.7%	1.4%	0.0%	0.7%
CyA + MMF/MPA + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.7%
Tac + MMF/MPA + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.0%	0.9%	2.9%	3.4%	11.2%	10.7%
Tac + OtherAntimet + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.7%	0.0%	0.8%	0.0%
--- + Steroids	0.0%	0.0%	0.0%	0.8%	0.7%	0.0%	0.7%	0.0%	0.0%	0.7%
CyA + Steroids	0.0%	0.0%	0.0%	0.0%	0.7%	0.9%	0.0%	0.0%	0.0%	0.0%
Tac + Steroids	9.8%	4.6%	9.7%	15.0%	13.6%	10.4%	12.4%	8.8%	24.0%	27.3%
--- + MMF/MPA + Steroids	0.0%	1.9%	1.1%	0.0%	1.4%	0.0%	0.0%	0.7%	0.0%	0.0%
CyA + MMF/MPA + Steroids	5.9%	5.6%	3.2%	4.2%	2.9%	2.6%	1.5%	1.4%	0.0%	0.0%
Tac + MMF/MPA + Steroids	74.5%	67.6%	52.7%	55.0%	37.9%	27.0%	23.4%	28.4%	20.8%	22.0%
--- + OtherAntimet + Steroids	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.7%	0.0%	0.0%	0.0%
CyA + OtherAntimet + Steroids	2.0%	0.9%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.7%
Tac + OtherAntimet + Steroids	7.8%	0.9%	4.3%	0.8%	0.0%	0.0%	2.2%	1.4%	0.0%	0.0%
--- + Siro/Evero + Steroids	0.0%	0.0%	2.2%	0.0%	1.4%	0.0%	1.5%	0.0%	0.0%	0.0%
CyA + Siro/Evero + Steroids	0.0%	0.9%	0.0%	0.0%	0.7%	0.9%	0.7%	0.0%	0.8%	0.7%
Tac + Siro/Evero + Steroids	0.0%	8.3%	12.9%	6.7%	11.4%	5.2%	2.9%	4.7%	0.0%	2.0%
Other Regimen	0.0%	2.8%	6.5%	0.8%	2.1%	6.1%	8.0%	0.7%	1.6%	2.0%

Source: OPTN/SRTR Data as of May 4, 2009.

Percentages are calculated based on the total number of patients with maintenance use at one year following transplantation. They sum to 100 percent for each column.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.