Table 15.14

Immunosuppression Use for Maintenance by Regimen

Two Years Following Transplantation, 1998 to 2006

Recipients with Lung Transplants

	Transplant Year
	1998	1999	2000	2001	2002	2003	2004	2005	2006
Transplants	893	922	977	1,083	1,054	1,099	1,185	1,407	1,406
Functioning Graft at 2 Years PostTx	543	583	658	719	752	790	872	994	1,023
With Maintenance Use Recorded at 2 Years PostTx	495	551	614	680	735	779	861	850	859
CyA	0.2%	0.2%	0.0%	0.1%	0.1%	0.0%	0.0%	0.0%	0.0%
Tac	1.0%	0.2%	0.0%	0.3%	0.1%	0.4%	0.2%	0.1%	0.1%
--- + MMF/MPA	0.2%	0.0%	0.2%	0.1%	0.1%	0.0%	0.1%	0.0%	0.0%
CyA + MMF/MPA	0.4%	0.2%	0.0%	0.3%	0.0%	0.1%	0.0%	0.0%	0.0%
Tac + MMF/MPA	0.2%	0.2%	0.3%	0.7%	0.5%	0.5%	0.7%	1.1%	0.9%
--- + OtherAntimet	0.0%	0.4%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
CyA + OtherAntimet	0.0%	0.2%	0.2%	0.1%	0.0%	0.0%	0.0%	0.0%	0.0%
Tac + OtherAntimet	0.4%	0.5%	0.2%	0.6%	1.0%	0.5%	0.1%	0.1%	0.0%
--- + Siro/Evero	0.4%	0.0%	0.0%	0.3%	0.0%	0.1%	0.0%	0.2%	0.1%
CyA + Siro/Evero	0.0%	0.2%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%	0.0%
Tac + Siro/Evero	0.2%	0.2%	0.2%	0.3%	0.1%	0.5%	0.1%	0.1%	0.1%
--- + MMF/MPA + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.1%	0.1%	0.0%	0.1%	0.0%
Tac + MMF/MPA + Siro/Evero	0.0%	0.0%	0.3%	0.1%	0.1%	0.1%	0.0%	0.0%	0.0%
--- + OtherAntimet + Siro/Evero	0.0%	0.0%	0.0%	0.0%	0.1%	0.1%	0.0%	0.0%	0.0%
Tac + OtherAntimet + Siro/Evero	0.0%	0.0%	0.0%	0.1%	0.1%	0.0%	0.0%	0.0%	0.1%
--- + Steroids	0.6%	0.7%	0.3%	0.6%	0.0%	0.6%	0.3%	0.4%	0.2%
CyA + Steroids	4.6%	4.9%	2.6%	1.2%	1.9%	1.7%	0.5%	2.0%	1.6%
Tac + Steroids	5.7%	5.1%	7.5%	8.1%	9.1%	9.6%	11.1%	10.8%	9.3%
--- + MMF/MPA + Steroids	0.6%	0.4%	0.5%	0.4%	0.5%	0.1%	0.2%	0.2%	0.2%
CyA + MMF/MPA + Steroids	13.3%	14.3%	14.7%	12.1%	8.8%	8.3%	5.5%	4.6%	4.5%
Tac + MMF/MPA + Steroids	22.8%	23.4%	27.9%	32.8%	35.1%	33.6%	41.8%	42.6%	46.9%
--- + OtherAntimet + Steroids	0.4%	0.2%	0.2%	0.3%	0.3%	0.1%	0.1%	0.1%	0.2%
CyA + OtherAntimet + Steroids	28.1%	22.1%	16.6%	7.5%	6.3%	7.6%	5.3%	4.5%	4.3%
Tac + OtherAntimet + Steroids	16.0%	16.3%	17.1%	17.4%	20.8%	20.7%	20.9%	18.6%	19.9%
--- + Siro/Evero + Steroids	0.2%	0.2%	0.2%	0.1%	0.4%	0.3%	0.5%	0.9%	0.5%
CyA + Siro/Evero + Steroids	0.2%	0.9%	1.3%	1.3%	0.7%	0.9%	0.3%	0.1%	0.2%
Tac + Siro/Evero + Steroids	1.6%	4.9%	4.4%	5.4%	6.3%	5.9%	4.9%	5.8%	4.1%
Other Regimen	2.8%	4.4%	5.5%	9.6%	7.2%	8.0%	7.2%	7.6%	6.5%

Source: OPTN/SRTR Data as of May 4, 2009.

Percentages are calculated based on the total number of patients with maintenance use at two years following transplantation. They sum to 100 percent for each column.

Transplants prior to year 1998 are not reported due to insufficient reporting of immunosuppressive drug use.

---: No Calcineurin Inhibitor Use; CyA: Cyclosporine; Tac: Tacrolimus.

MMF: Mycophenolate Mofetil; MPA: Mycophenolate Sodium; Siro: Sirolimus; Evero: Everolimus; OtherAntimet: Antimetabolites excluding MMF and MPA.

"Other Regimen" includes drug combinations that are different from the listed regimens and drugs from the text field entering.