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Table 15.6

Steroid Withdrawal Rate at Two Years Following Transplantation, 1998 to 2006

Recipients of Heart Transplants

Discharge Regimen Year of Transplant
1999 2000 2001 2002 2003 2004 2005 2006
Total Patients 1,482 1,558 1,581 1,561 1,458 1,432 1,362 1,332
Steroids Withdrawn 422 471 558 546 556 579 584 604
Rate 28.5% 30.2% 35.3% 35.0% 38.1% 40.4% 42.9% 45.3%
CyA Patients 176 66 28 39 22 10 9 20
Steroids Withdrawn 48 21 9 21 9 5 3 3
Rate 27.3% 31.8% 32.1% 53.8% 40.9% 50.0% 33.3% 15.0%
Tac Patients 37 31 56 58 39 30 28 22
Steroids Withdrawn 21 17 21 26 11 21 15 16
Rate 56.8% 54.8% 37.5% 44.8% 28.2% 70.0% 53.6% 72.7%
CyA+MMF Patients 640 903 863 699 676 615 475 435
Steroids Withdrawn 156 245 268 237 243 240 187 177
Rate 24.4% 27.1% 31.1% 33.9% 35.9% 39.0% 39.4% 40.7%
Tac+MMF Patients 95 130 300 364 425 560 643 687
Steroids Withdrawn 27 39 139 127 172 231 317 332
Rate 28.4% 30.0% 46.3% 34.9% 40.5% 41.3% 49.3% 48.3%
CyA+Aza Patients 388 244 162 101 73 61 33 30
Steroids Withdrawn 127 95 59 28 28 16 8 17
Rate 32.7% 38.9% 36.4% 27.7% 38.4% 26.2% 24.2% 56.7%
Tac+Aza Patients 29 32 21 20 19 16 14 18
Steroids Withdrawn 7 7 5 3 6 5 8 6
Rate 24.1% 21.9% 23.8% 15.0% 31.6% 31.3% 57.1% 33.3%
CyA+Siro Patients 10 10 3 17 33 2 1 1
Steroids Withdrawn 5 6 1 13 24 1 0 0
Rate 50.0% 60.0% 33.3% 76.5% 72.7% 50.0% 0.0% 0.0%
Tac+Siro Patients 0 15 30 97 30 12 14 11
Steroids Withdrawn - 0 3 34 12 10 7 8
Rate - 0.0% 10.0% 35.1% 40.0% 83.3% 50.0% 72.7%
Siro+MMF Patients - - 3 5 16 14 13 15
Steroids Withdrawn - - 1 0 4 1 3 6
Rate - - 33.3% 0.0% 25.0% 7.1% 23.1% 40.0%
Other Regimen Patients 107 127 115 161 125 112 132 93
Steroids Withdrawn 31 41 52 57 47 49 36 39
Rate 29.0% 32.3% 45.2% 35.4% 37.6% 43.8% 27.3% 41.9%


Source: OPTN/SRTR Data as of May 4, 2009.

Includes patients receiving first transplants of any organ with steroid use at transplant discharge, and who have a functioning graft and maintenance drug use two years after transplantation.

Transplants prior to year 1998 are not reported due to insufficient reporting of immunosuppressive drug use.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.



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