Table 8.6h

Persistency of Discharge Regimen by Follow-up Period, 1999 to 2003

Recipients with Kidney-Pancreas Transplants

  Year of Transplant
1999 2000 2001 2002 2003
Discharge Regimen (w/ or w/o Steroid Use) CyA+Aza At Discharge (N) 1 3 1 - -
At Discharge (%) 100.0% 100.0% 100.0% - -
6 Months PostTx (%) 0.0% 33.3% 0.0% - -
1 Year PostTx (%) 0.0% 33.3% 0.0% - -
2 Years PostTx (%) 0.0% 33.3% 0.0% - -
3 Years PostTx (%) 0.0% 33.3% 0.0% - -
CyA+MMF At Discharge (N) 175 106 73 61 45
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 75.2% 75.5% 80.8% 78.4% 79.5%
1 Year PostTx (%) 67.3% 69.7% 72.6% 74.9% 69.4%
2 Years PostTx (%) 62.2% 59.2% 62.8% 69.1% 69.4%
3 Years PostTx (%) 59.7% 52.2% 61.1% 69.1% -
CyA+Siro At Discharge (N) - 22 14 5 26
At Discharge (%) - 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) - 72.7% 85.7% 60.0% 84.6%
1 Year PostTx (%) - 68.2% 85.7% 20.0% 68.7%
2 Years PostTx (%) - 59.1% 78.6% - -
3 Years PostTx (%) - 50.0% 68.8% - -
Siro+MMF At Discharge (N) 1 2 10 5 30
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 100.0% 100.0% 70.0% 0.0% 63.3%
1 Year PostTx (%) 0.0% 100.0% 60.0% 0.0% 63.3%
2 Years PostTx (%) 0.0% 100.0% 60.0% 0.0% 63.3%
3 Years PostTx (%) 0.0% 0.0% 50.0% 0.0% -
Tac+Aza At Discharge (N) 10 10 1 5 6
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 60.0% 30.0% 100.0% 60.0% 50.0%
1 Year PostTx (%) 50.0% 20.0% 100.0% 60.0% 25.0%
2 Years PostTx (%) 40.0% 20.0% - 60.0% -
3 Years PostTx (%) 30.0% 10.0% - - -
Tac+MMF At Discharge (N) 597 574 530 578 561
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 79.7% 84.5% 83.8% 82.9% 80.5%
1 Year PostTx (%) 70.7% 77.7% 75.7% 71.8% 73.5%
2 Years PostTx (%) 64.6% 67.8% 65.8% 65.3% 56.5%
3 Years PostTx (%) 57.6% 60.4% 58.0% 52.2% -
Tac+Siro At Discharge (N) 6 63 110 104 71
At Discharge (%) 100.0% 100.0% 100.0% 100.0% 100.0%
6 Months PostTx (%) 16.7% 74.2% 83.4% 76.9% 81.4%
1 Year PostTx (%) 16.7% 69.1% 74.8% 70.2% 61.9%
2 Years PostTx (%) 16.7% 55.5% 66.9% 59.3% 61.9%
3 Years PostTx (%) 16.7% 41.2% 47.2% 59.3% -


Source: OPTN/SRTR Data as of May 2, 2005.

Regimen change is defined as being on different drug combination at follow-up comparing to discharge, or indication of conflicting regimen(CyA vs. Tac; MMF/MPA vs. Aza; Siro vs. Evero) during follow-up peroid, or graft failure/death. Addition or deletion of steroids is not considered a regimen change.Rates are calculated for the most common discharge regimens.

CyA: Cyclosporine; Tac: Tacrolimus; MMF: Include MMF(Mycophenolate Mofetil) and MPA(Mycophenolate Sodium); Aza: Azathioprine; Siro: Sirolimus.

See Technical Notes for further details.